MitoPrime as Anti-Inflammatory

1. Rahman, I., et al., Ergothioneine inhibits oxidative stress- and TNF-alpha-induced NF- kappa B activation and interleukin-8 release in alveolar epithelial cells. Biochem Biophys Res Commun, 2003. 302(4): p. 860-4.
2. Sakrak, O., et al., Ergothioneine modulates proinflammatory cytokines and heat shock protein 70 in mesenteric ischemia and reperfusion injury. J Surg Res, 2008. 144(1): p. 36-42.
3. Ergothioneine inhibits oxidative stress- and TNF-alpha-induced NF-kappa B activation and interleukin-8 release in alveolar epithelial cells
   Irfan Rahman 1, Peter S Gilmour, Luis A Jimenez, Saibal K Biswas, Frank Antonicelli, Okezie I Aruoma
4. Ergothioneine; antioxidant potential, physiological function and role in disease☆
   Author links open overlay panelIrwin K.CheahBarryHalliwell
5. Repine, J.E. and N.D. Elkins, Effect of ergothioneine on acute lung injury and inflammation in cytokine insufflated rats. Prev Med, 2012. 54 Suppl(Suppl): p. S79-82.
6. Ergothioneine as an Anti-Oxidative/Anti-Inflammatory Component in Several Edible Mushrooms
   March 2011Food Science and Technology Research 17(2):103-110
   DOI: 10.3136/fstr.17.103
   Ergothioneine inhibits oxidative stress- and TNF–induced NF-B activation and interleukin-8 release in alveolar epithelial cells
   April 2003Biochemical and Biophysical Research Communications 302(4):860-4
   DOI: 10.1016/S0006-291X(03)00224-9
   SourcePubMed
7. Modulation of palmitic acid-induced cell death by ergothioneine: evidence of an anti-inflammatory action Incoronata Laurenza 1, Renato Colognato, Lucia Migliore, Stefano Del Prato, Luca Benzi

MitoPrime & Cell Health

1. Increase in cell viability of 45%
   The unusual amino acid L-ergothioneine is a physiologic cytoprotectantBD Paul1 and SH Snyder*,1,2,3
2. Protection of mitochondrial DNA
   The unusual amino acid L-ergothioneine is a physiologic cytoprotectantBD Paul1 and SH Snyder*,1,2,3
3. Inhibits premature cell death
   The unusual amino acid L-ergothioneine is a physiologic cytoprotectantBD Paul1 and SH Snyder*,1,2,3
4. Anti-inflammatory action
   Ergothioneine as an Anti-Oxidative/Anti-Inflammatory Component in Several Edible MushroomsMarch 2011Food Science and Technology Research 17(2):103-110DOI: 10.3136/fstr.17.103
5. Protection of the cell’s lipid membrane
   Dong K K, Damaghi N, Kibitel J, et al. Journal of Cosmetic Dermatology, 2007,

MitoPrime & Immunity

1. Could Ergothioneine Aid in the Treatment of Coronavirus Patients?Cheah IK, Halliwell B.

   Antioxidants (Basel). 2020 Jul 7;9(7):595. doi: 10.3390/antiox9070595.

   PMID: 32646061 Free PMC article. Review.

2. Antiinflammatory and Immunomodulating Properties of Fungal Metabolites
   Cristina Lull,1 Harry J. Wichers,1 and Huub F. J. Savelkoul2,*Mediators Inflamm. 2005 Jun 9; 2005(2): 63–80.

   doi: 10.1155/MI.2005.63

   PMCID: PMC1160565

   PMID: 16030389

3. The Anti-Oxidant Ergothioneine Augments the Immunomodulatory Function of TLR Agonists by Direct Action on MacrophagesSumito Yoshida ,Hiroaki Shime ,Kenji Funami,Hiromi Takaki,Misako Matsumoto,Masanori Kasahara,Tsukasa Seya

   Published: January 23, 2017https://doi.org/10.1371/journal.pone.0169360

4. Organic cation transporter Octn1-mediated uptake of food-derived antioxidant ergothioneine into infiltrating macrophages during intestinal inflammation in mice
   Takuya Shimizu 1, Yusuke Masuo 1, Saki Takahashi 1, Noritaka Nakamichi 1, Yukio Kato 2Affiliations expand

   PMID: 26003890 DOI: 10.1016/j.dmpk.2015.02.003

5. Ergothioneine antioxidant function on macrophages
   Oxidative stress and macrophage function: a failure to resolve the inflammatory responseBiochem Soc Trans

   2007 Apr;35(Pt 2):284-7. doi: 10.1042/BST0350284.

6. The Anti-Oxidant Ergothioneine Augments the Immunomodulatory Function of TLR Agonists by Direct Action on Macrophages
   Sumito Yoshida ,Hiroaki Shime ,Kenji Funami,Hiromi Takaki,Misako Matsumoto,Masanori Kasahara,Tsukasa SeyaPublished: January 23, 2017https://doi.org/10.1371/journal.pone.0169360
7. Current studies underway based on past studies on mushroom extracts
   Antiinflammatory and Immunomodulating Properties of Fungal Metabolites
   Cristina Lull,1 Harry J. Wichers,1 and Huub F. J. Savelkoul2,*Mediators Inflamm. 2005 Jun 9; 2005(2): 63–80. doi: 10.1155/MI.2005.63

   PMCID: PMC1160565 PMID: 16030389

8. Current studies underway based on past studies on mushroom polysaccharides
   Induction of a T-Helper 1 (Th1) Immune Response in Mice by …www.ncbi.nlm.nih.gov › pmc › articles › PMC3523248

MitoPrime as Antioxidant

“Genomic stability is the #1 predictor of longevity”

1. Ergothioneine and hypochlorous and hypobromous acids
   A mushroom-derived amino acid, ergothioneine, is a potential inhibitor of inflammation-related DNA halogenationBiosci Biotechnol Biochem

   . 2016;80(2):313-7. doi: 10.1080/09168451.2015.1083396. Epub 2015 Sep 4.

   Takashi Asahi 1 2, Xiaohong Wu 2 3, Hiroshi Shimoda 4, Shinsuke Hisaka 5, Etsuko Harada 6, Tomomi Kanno 7, Yoshimasa Nakamura 1, Yoji Kato 8, Toshihiko Osawa 2 9

2. Ergothioneine and singlet oxygen elimination

    

   Deactivation of singlet molecular oxygen
   by thiols and related compounds, possible
   protectors against skin photosensitivity
   M. Rougee’r, . ,V.B Ensassone’,. J. Land^.* and R. Pariente3

   ‘Laboratoire de Biophysique, INSERM U.201, CNRS UA 481, Museum National d’Histoire

   Naturelle, 61 rue Buffon-75005 Paris, France, 2Paterson Institute for Cancer Research, Christie

   Hospital and Holt Radium Institute, Manchester M20 9BX, England, UK, 3Departement de
   Pneumologie et de

MitoPrime & Genomic Stability

1. “Genomic stability is the #1 predictor of longevity”

    

   The Hallmarks of Aging

   Carlos López-Otín,1 Maria A. Blasco,5 Linda Partridge,3,4 Manuel Serrano,2,* and Guido Kroemer6,7,8,9,10

   Cell. Author manuscript; available in PMC 2013 Nov 21. PMCID: PMC3836174 EMSID: EMS55354

   PMID: 23746838 Published in final edited form as: Cell. 2013 Jun 6; 153(6): 1194–1217. doi: 10.1016/j.cell.2013.05.039

2. Ergothioneine and Hypochlorous; Hypobromous Acids

    

   NIH; PubMed.gov; Biosci Biotechnol Biochem. 2016;80(2):313-7. doi: 10.1080/09168451.2015.1083396.

   Epub 2015 Sep 4. PMID: 26338495 DOI: 10.1080/09168451.2015.1083396

3. Ergothioneine eliminates singlet oxygen radical up to 7,500% better than any known antioxidant

   Rougee M, Bensasson R V, Land E J, et al. Photochemistry and Photobiology, 1988, 47(4):485-489.

4. Ergothioneine half life 44,000 times longer than glutathione

    

   Gluthathione: Pharmacokinetics of Glutathione and Its Metabolites in Normal Subjects; Rougee M, Bensasson R V, Land E J, et al.

   Photochemistry and Photobiology, 1988, 47(4):485-489. J Korean Med Sci. 2005 Oct; 20(5): 721–726. Published online 2005 Oct 31.

   doi: 10.3346/jkms.2005.20.5.721 PMCID: PMC2779265 PMID: 16224142

    

   Ergothioneine: The unusual amino acid l-ergothioneine is a physiologic cytoprotectant BD Paul1 and SH Snyder

   Cell Death Differ. Author manuscript; available in PMC 2010 Aug 1. Published in final edited form as: Cell Death Differ. 2010 Jul; 17(7): 1134–1140. Published online 2009 Nov 13. doi: 10.1038/cdd.2009.163

   PMCID: PMC2885499 NIHMSID: NIHMS187988 PMID: 19911007

5. Ergothioneine as an Anti-Oxidative and Anti-Inflammatory

   Article in Food Science and Technology Research 17(2):103-110 · March 2011 with 85 Reads DOI: 10.3136/fstr.17.103

6. Discovery of the ergothioneine transporter

   Dirk Gründemann,*†‡ Stephanie Harlfinger,* Stefan Golz,§ Andreas Geerts, Andreas Lazar,* Reinhard Berkels,*

   Norma Jung, Andrea Rubbert, and Edgar Schömig* Rougee M, Bensasson R V, Land E J, et al. Photochemistry and Photobiology, 1988, 47(4):485-489.

   Proc Natl Acad Sci U S A. 2005 Apr 5; 102(14): 5256–5261. Published online 2005 Mar 28. doi: 10.1073/pnas.0408624102 PMCID: PMC555966 PMID: 15795384 Pharmacology

7. Crosstalk between nuclear and mitochondrial genomes

   R O Poyton 1, J E McEwen

   Affiliations expand

   PMID: 8811190 DOI: 10.1146/annurev.bi.65.070196.003023