The #1 Predictor of Longevity

“MitoPrime may very well be the first bona fide genomic stabilizer”

“Genomic stability is the #1 predictor of longevity” (1)

  1. Not long ago a group of international scientists was formed to review all literature, theories and scientific research on aging.
  2. They were tasked with scientifically de-coding the aging process while providing steps we can all take to increase longevity.
  3. After many years of research, their main conclusion was, “genomic stability is the #1 predictor of longevity” and “healthy DNA creates genomic stability.”

The “axis of aging”

  • All causes of aging are relatively intertwined.
  • Genomic instability is considered the “master domino,” triggering all the subordinate causes of aging
  • DNA damage is the direct cause of genomic instability

The conclusion

“There is an important reason why ‘genomic instability’ takes
the number one position on the list of the hallmarks of aging.

Ultimately, genomic instability influences every single parameter, process and outcome of all the other hallmarks.

The cause of genomic instability is DNA damage.”

Source: Excerpted from the published “The Hallmarks of Aging” study

The “Hallmarks of Aging”
PubMed: PMCID: PMC3836174;
EMSID: EMS55354; PMID: 23746838

MitoPrime, because a stable genome means a long healthy life

MitoPrime and DNA protection

Your body has two types of DNA. The first is nuclear DNA (nDNA), with the famous double helix design. As its name implies, it resides in the cell’s nucleus and carries over 99% of your genetic material. The second type is mitochondrial DNA (mtDNA), with a circular shape. Although it doesn’t get the press coverage of its nuclear relative, mitochondrial DNA is equally important regarding your health and longevity.

Nuclear DNA: nuclear DNA is responsible for the proper production the structural and functional proteins you need to survive.

Mitochondrial DNA: mitochondrial DNA keeps your body’s sole energy source, your mitochondria, functioning properly.

MitoPrime protects both types of DNA and helps create genomic stability. MitoPrime scavenges and eliminates the most harmful
DNA-damaging elements.

0

1

Problem:

Hypochlorous acid and hypobromous acid

These lethal acids are the most destructive forces to DNA. They’re known as chlorine reactive species. They covalently attach themselves to DNA causing mutations that replicate.(2)

Solution:

MitoPrime easily and efficiently scavenges hypochlorous acid and hypobromous acid. We believe that MitoPrime is the only ingredient that can make that claim.

2

Problem:

Singlet oxygen radical

Singlet oxygen is the most pernicious DNA-damaging of all reactive oxygen species. It destroys lipids, proteins, nucleic acids, and causes lesions, breaks, and mutations.

Solution:

MitoPrime eliminates the singlet oxygen radical MitoPrime eliminates the pernicious singlet oxygen radical up to 75 times better than any known oral antioxidant.(3) What’s more, MitoPrime is the longest acting antioxidant ever known, lasting 4,517 times longer than glutathione. (4)

3

Problem

Inflammation

Inflammation causes production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) that attack DNA, altering its chemical base structure, leading to DNA mutations.

Solution

MitoPrime reduces inflammation and eliminates ROS and RNS. MitoPrime is proven to both inhibit and reduce inflammation while eliminating DNA-damaging reactive oxygen species (ROS) and reactive nitrogen species (RNS).(5)

MitoPrime: mitochondrial DNA protection

Your body has two types of DNA. The first is nuclear DNA (nDNA), with the famous double helix design. As its name implies, it resides in the cell’s nucleus and carries over 99% of your genetic material. The second type is mitochondrial DNA (mtDNA), with a circular shape. Although it doesn’t get the press coverage of its nuclear relative, mitochondrial DNA is equally important regarding your health and longevity.

Nuclear DNA: nuclear DNA is responsible for the proper production the structural and functional proteins you need to survive.

Mitochondrial DNA: mitochondrial DNA keeps your body’s sole energy source, your mitochondria, functioning properly.

MitoPrime protects both types of DNA and helps create genomic stability. MitoPrime scavenges and eliminates the most harmful
DNA-damaging elements.

  • Nearly 100% of all free radicals are generated inside the mitochondria. Only MitoPrime (ergothioneine) has specific, and dedicated, nutrient transporters centered directly in the mitochondria. All other antioxidants have to compete for entry into the cell, not MitoPrime.
  • The high level of evolutionary-conserved ergothioneine transporters in the mitochondria prove how vital ergothioneine is to the protection of mitochondria.(6)
  • New studies show that mitochondrial DNA and nuclear DNA “cross talk” with each other. Each keeping the other fully operational. MitoPrime protects both nuclear and mitochondrial DNA, helping to preserve the vital intra-cellular communication that leads to genomic stability.
  • MitoPrime is the only antioxidant agent that simultaneously acts as a powerful anti-inflammatory. That’s important because inflammation damages mitochondria, and damaged mitochondria trigger more inflammation. MitoPrime helps end this vicious cycle.

Clinical Citations

  1. “Genomic stability is the #1 predictor of longevity”

     

    The Hallmarks of Aging

    Carlos López-Otín,1 Maria A. Blasco,5 Linda Partridge,3,4 Manuel Serrano,2,* and Guido Kroemer6,7,8,9,10

    Cell. Author manuscript; available in PMC 2013 Nov 21. PMCID: PMC3836174 EMSID: EMS55354

    PMID: 23746838 Published in final edited form as: Cell. 2013 Jun 6; 153(6): 1194–1217. doi: 10.1016/j.cell.2013.05.039

  2. Ergothioneine and Hypochlorous; Hypobromous Acids

     

    NIH; PubMed.gov; Biosci Biotechnol Biochem. 2016;80(2):313-7. doi: 10.1080/09168451.2015.1083396.

    Epub 2015 Sep 4. PMID: 26338495 DOI: 10.1080/09168451.2015.1083396

  3. Ergothioneine eliminates singlet oxygen radical up to 7,500% better than any known antioxidant

    Rougee M, Bensasson R V, Land E J, et al. Photochemistry and Photobiology, 1988, 47(4):485-489.

  4. Ergothioneine half life 44,000 times longer than glutathione

     

    Gluthathione: Pharmacokinetics of Glutathione and Its Metabolites in Normal Subjects; Rougee M, Bensasson R V, Land E J, et al.

    Photochemistry and Photobiology, 1988, 47(4):485-489. J Korean Med Sci. 2005 Oct; 20(5): 721–726. Published online 2005 Oct 31.

    doi: 10.3346/jkms.2005.20.5.721 PMCID: PMC2779265 PMID: 16224142

     

    Ergothioneine: The unusual amino acid l-ergothioneine is a physiologic cytoprotectant BD Paul1 and SH Snyder

    Cell Death Differ. Author manuscript; available in PMC 2010 Aug 1. Published in final edited form as: Cell Death Differ. 2010 Jul; 17(7): 1134–1140. Published online 2009 Nov 13. doi: 10.1038/cdd.2009.163

    PMCID: PMC2885499 NIHMSID: NIHMS187988 PMID: 19911007

  5. Ergothioneine as an Anti-Oxidative and Anti-Inflammatory

    Article in Food Science and Technology Research 17(2):103-110 · March 2011 with 85 Reads DOI: 10.3136/fstr.17.103

  6. Discovery of the ergothioneine transporter

    Dirk Gründemann,*†‡ Stephanie Harlfinger,* Stefan Golz,§ Andreas Geerts, Andreas Lazar,* Reinhard Berkels,*

    Norma Jung, Andrea Rubbert, and Edgar Schömig* Rougee M, Bensasson R V, Land E J, et al. Photochemistry and Photobiology, 1988, 47(4):485-489.

    Proc Natl Acad Sci U S A. 2005 Apr 5; 102(14): 5256–5261. Published online 2005 Mar 28. doi: 10.1073/pnas.0408624102 PMCID: PMC555966 PMID: 15795384 Pharmacology

  7. Crosstalk between nuclear and mitochondrial genomes

    R O Poyton 1, J E McEwen

    Affiliations expand

    PMID: 8811190 DOI: 10.1146/annurev.bi.65.070196.003023