Boost your immunity, for life

Multiple studies show how MitoPrime boosts your innate and adaptive immune response.

Today, more than ever, maintaining a strong immune system is essential, but our modern lifestyles can put us a risk. That includes everything from poor diet, sedentary lifestyle, too much exercise, pesticides, excessive alcohol, smoking, ultraviolet radiation and inflammation. According to the National Institutes of Health, prolonged periods of intense stress, grief and even loneliness can lower immune function.

But multiple studies on MitoPrime (L-ergothioneine) demonstrate how it can bolster your immune function, even in the face of the stresses working against it. In fact, on July 7, 2020, a published review on ergothioneine went so far as to show how it may have a significant role in mitigating the effects of COVID-19.(1)

MitoPrime and your immune system

Your immune system is made up of two parts, each with its own set of functions and responsibilities. They are known as ‘innate immunity’ and ‘adaptive immunity.’

Innate system

Your innate immune system provides the first line of defense against microbes. The macrophages are the key players here, as their purpose is to engulf the invading pathogens, and destroy them. Consider them your rapid responders. If they are not successful after 12 hours, your adaptive system kicks in.

Adaptive system

Your adaptive system has the ability to identify specific pathogens and respond with a variety of substances. Your adaptive system has ‘memory’ and responds more vigorously to repeated exposures to the same microbe. Natural killer (NK) cells play a central role here, as they attack and destroy the pathogens.

MitoPrime

Listen to this recent clinical finding: “supplementation with ergothioneine (MitoPrime) can result in a more enhanced innate and adaptive disease resistance.”(2)

Macrophage engulfing and destroying bacteria
NK cell attacking pathogen

Clinical highlights that show how MitoPrime boosts the innate immune system

  1. “Ergothioneine significantly increases macrophage activity.” (3)
  2. “Macrophages take up ergothioneine on first pass to prevent oxidative damage” (4)
  3. “Ergothioneine can prevent free radical-produced toxic stress and death of macrophages.” (5)
  4. “Ergothioneine potentiates toll-like receptor signaling on macrophages surfaces, providing greater and faster ecognition of pathogens.” (6)

Clinical highlights that show how MitoPrime boosts the adaptive immune system

  1. “The major immuno-modulating effects of ergothioneine include mitogenicity* and activation of immune effector cells, such as lymphocytes, macrophages, and natural killer cells.”(7)
  2. “In particular, the ability of ergothioneine to modulate the differentiation capacity of CD4+ T cells to mature into TH1 and/or TH2 subsets greatly boosts immune strength.”(8)

*Mitogenicity
The act of a mitogen that induces changes in DNA, RNA, protein synthesis, and proliferation of lymphocytes; e.g., concanavalin A, phytohemagglutinin, or lipopolysaccharide.

Relevant New Published Study

Could Ergothioneine Aid in the Treatment of Coronavirus Patients?

Could Ergothioneine Aid in the Treatment of Coronavirus Patients?
Received: 4 June 2020; Accepted: 2 July 7, 2020; Published: 7 July, 2020

Extreme viruses, such as COVID-19, often leave their mark long after a person has recovered. Especially vulnerable are the heart, lungs, and brain. MitoPrime’s active, L-ergothioneine, helps in both underlying conditions and after effects.

The lungs

Studies show that MitoPrime (ergothioneine, in the optimized form) protects lungs by inhibiting pulmonary epithelial-mesenchymal transition, a key event in pulmonary fibrosis. Interestingly, MitoPrime (ergothioneine) also has the ability to protect the lung’s epithelial cells from the damaging effects of cigarette smoke.

The brain / cognition

COVID-19 can lead to lasting neurological (nerve system) symptoms in the brain, especially as it affects the thalamus, cerebrum, and brainstem. But research says MitoPrime’s (ergothioneine) neuro-protective properties may offer major help.

The study cites research proving that ergothioneine protects against a range of neurotoxins, such as amyloid and cisplatin.

And researchers are quick to point out that people with mild cognitive impairment exhibit significantly lower blood levels of ergothioneine. This all suggests that ergothioneine may be a valuable asset in dealing with the potential residual conditions caused by extreme viruses

The heart

Studies show that ergothioneine is associated with reduced mortality and decreased risk of cardiovascular disease. According to another study…“Intake of ergothioneine would be a prudent medicinal means of reducing CVD risk.”

Clinical Citations

  1. Could Ergothioneine Aid in the Treatment of Coronavirus Patients?
    Cheah IK, Halliwell B.Antioxidants (Basel). 2020 Jul 7;9(7):595. doi: 10.3390/antiox9070595.

    PMID: 32646061 Free PMC article. Review.

  2. Antiinflammatory and Immunomodulating Properties of Fungal Metabolites
    Cristina Lull,1 Harry J. Wichers,1 and Huub F. J. Savelkoul2,*
    Mediators Inflamm. 2005 Jun 9; 2005(2): 63–80.doi: 10.1155/MI.2005.63

    PMCID: PMC1160565

    PMID: 16030389

  3. The Anti-Oxidant Ergothioneine Augments the Immunomodulatory Function of TLR Agonists by Direct Action on Macrophages
    Sumito Yoshida ,Hiroaki Shime ,Kenji Funami,Hiromi Takaki,Misako Matsumoto,Masanori Kasahara,Tsukasa SeyaPublished: January 23, 2017https://doi.org/10.1371/journal.pone.0169360
  4. Organic cation transporter Octn1-mediated uptake of food-derived antioxidant ergothioneine into infiltrating macrophages during intestinal inflammation in mice
    Takuya Shimizu 1, Yusuke Masuo 1, Saki Takahashi 1, Noritaka Nakamichi 1, Yukio Kato 2
    Affiliations expandPMID: 26003890 DOI: 10.1016/j.dmpk.2015.02.003
  5. Ergothioneine antioxidant function on macrophages
    Oxidative stress and macrophage function: a failure to resolve the inflammatory response
    Biochem Soc Trans2007 Apr;35(Pt 2):284-7. doi: 10.1042/BST0350284.
  6. The Anti-Oxidant Ergothioneine Augments the Immunomodulatory Function of TLR Agonists by Direct Action on Macrophages
    Sumito Yoshida ,Hiroaki Shime ,Kenji Funami,Hiromi Takaki,Misako Matsumoto,Masanori Kasahara,Tsukasa Seya
    Published: January 23, 2017https://doi.org/10.1371/journal.pone.0169360
  7. Current studies underway based on past studies on mushroom extracts
    Antiinflammatory and Immunomodulating Properties of Fungal Metabolites
    Cristina Lull,1 Harry J. Wichers,1 and Huub F. J. Savelkoul2,*
    Mediators Inflamm. 2005 Jun 9; 2005(2): 63–80. doi: 10.1155/MI.2005.63PMCID: PMC1160565 PMID: 16030389
  8. Current studies underway based on past studies on mushroom polysaccharides
    Induction of a T-Helper 1 (Th1) Immune Response in Mice by …www.ncbi.nlm.nih.gov › pmc › articles › PMC3523248